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Within a analyze in breast cancer cells, The mixture of lapatinib, a dual HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented both of those HER2 and HER3 phosphorylation induced by INK128 and manufactured synergistic induction of cell Dying in various HER2-positive cell strains resistant to trastuzumab and lapatinib. In vivoDUSP18, a